Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct

X Luan, JS Tam, S Jagadeeshan… - … of Physiology-Lung …, 2020 - journals.physiology.org
… of the fluid produced by the individual submucosal glandsCFTR-dependent gland secretion,
triggered serous acini epithelia … Acinar origin of CFTR-dependent airway submucosal gland

Neuropeptide regulation of secretion and inflammation in human airway gland serous cells

DB McMahon, RM Carey, MA Kohanski… - … Respiratory Journal, 2020 - Eur Respiratory Soc
Airway submucosal gland serous cells are sites of … defects in CFTR-dependent serous
secretion contribute to CF … Gland acini are likely significant contributors of cytokines [54]…

Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia

K Okuda, H Dang, Y Kobayashi, G Carraro… - … journal of respiratory …, 2021 - atsjournals.org
… in the regulation of airway epithelial Cl − and fluid secretory rates. … Airway submucosal
glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs

W Yu, TO Moninger, AL Thurman… - Proceedings of the …, 2022 - National Acad Sciences
… SMGs secrete liquid and most of the mucus in large airways; the … To better understand the
potential role of the two acinar cell types in electrolyte and liquid secretion, we also curated a …

PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa

DB McMahon, RM Carey… - … of Physiology-Lung …, 2021 - journals.physiology.org
… of synergistic CFTR-dependent PAR-2/VIPR secretion may … structure of an airway submucosal
gland, showing cystic … at the distal acini, which have been demonstrated to be the origin of …

[HTML][HTML] CFTR-rich ionocytes mediate chloride absorption across airway epithelia

L Lei, S Traore, GSR Ibarra, PH Karp… - The Journal of …, 2023 - Am Soc Clin Investig
… -airway epithelia and submucosal glands, thus determining … absorption and CFTR-dependent
liquid secretion. Our … CFTR within the acinus and ducts of the airway epithelium could …

[HTML][HTML] Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium

D Angyal, TA Groeneweg, A Leung, M Desain… - Cellular & Molecular …, 2024 - Springer
Background … activity of NFκB in acinar cells, which, together with the release of damage-associated …
CFTR-mediated fluid secretion in the submucosal glands of the respiratory tract, and …

VSI: The Anoctamins: Structure and Function

R Schreiber, J Ousingsawat, K Kunzelmann - Cell Calcium, 2024 - Elsevier
… Cl − by ANO1 takes place in secretory acini and intercalated cells of salivary glands and …
supports CFTR-dependent fluid and mucus secretion especially in airway submucosal glands […

Stem cells of submucosal glands: Their function as tissue stem cells and a reserve population for airway repair

A Tata - Eur Respir Monogr, 2021 - books.google.com
… At 18 weeks, acini and secreting mucous tubules start to … CGRP stimulates CFTR-dependent
SMG secretions and is … Hyperacidity of secreted fluid from submucosal glands in early …

Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis

T Kato, G Radicioni, MJ Papanikolas, GV Stoychev… - Science …, 2022 - science.org
… Collectively, these data suggest that anion/fluid secretion … , a product of abnormal
CFTR-dependent mucus hydration (… (nonsmokers without any history of respiratory diseases), CF, …